The Indians resisted the yoke, and many died in resistance

The Spanish missions were established in California late in the 18th century. They were the work of father Serra who'd walked on his martyrs bare feet from Mexico to Monterey. A garrulous fanatic, Serra committed himself to "slipping the gentle yoke of Christ” over the heads of "neophytes," as unyoked Indians were called by the Franciscans, all of whom had been born in Spain. 
The Indians resisted the yoke, and many died in a resistance so fierce and unyielding that they killed the babies born of rapes by the Spanish soldiers who accompanied the missionaries up and down Spanish California from San Diego to San Rafael and Sonoma.